A DNA sensor based on upconversion nanoparticles and two-dimensional dichalcogenide materials

Abstract We demonstrate the fabrication of a new DNA sensor that is based on optical interactions occurring between oligonucleotide-coated NaYF 4 :Yb 3+ ;Er upconversion nanoparticles and two-dimensional dichalcogenide materials, MoS 2 WS . Monodisperse were functionalized with single-stranded endowing ability to interact surface materials via van der Waals leading subsequent quenching fluorescence. By contrast, in presence complementary oligonucleotide target formation double-stranded DNA, could not , thus retaining their inherent fluorescence properties. Utilizing this we able detect oligonucleotides high sensitivity specificity whilst reaching concentration detection limit as low 5 mol·L −1 within minutes.